association of polymorphism at 3׳-utr of urokinase gene with risk of calcium kidney stones

urokinase might play a role in the formation of kidney stones. this study was done to determine the association between +4065 t/c polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. this case-control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the baqiyatallah hospital of tehran in 2013. the study of polymorphism was performed by allele-specific pcr method. mutant t allele frequency was %41 in cases and %18 in controls. hardy-weinberg equilibrium (hwe) was tested using chi-square test. the chi-square showed that the control population is in hwe, and as expected, the patient group does not follow hwe. the odds ratio for the risk of the t allele was 1.7 (%95 confidence interval 0.2988-1.158). a significant association was found between the urokinase gene t/c polymorphism and the formation of calcium kidney stones. also, effect modification was examined for both sexes and different age groups. according to the results, t polymorphism in the 3’-utr of urokinase gene may increase with age.